Characterization of cathepsin S exosites that govern its elastolytic activity
نویسندگان
چکیده
منابع مشابه
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
BACKGROUND Clinical studies have demonstrated that 50% of individuals with chronic renal disease (CRD) die of cardiovascular causes, including advanced calcific arterial and valvular disease; however, the mechanisms of accelerated calcification in CRD remain obscure, and no therapies can prevent disease progression. We recently demonstrated in vivo that inflammation triggers cardiovascular calc...
متن کاملStimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G.
Human leukocyte cathespin G strongly stimulates the rate of solubilization of human lung elastin by human leukocyte elastase. For instance, the elastolytic activity of an equimolar mixture of elastase and cathepsin G is more than 5 times higher than that of elastase alone. Optimal stimulation occurs only if cathepsin G and elastase act simultaneously on elastin. Potentiation of leukocyte elasta...
متن کاملCathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.
Atherosclerosis is characterized by a thickening and loss of elasticity of the arterial wall. Loss of elasticity has been attributed to the degradation of the arterial elastin matrix. Cathepsins K and S are papain-like cysteine proteases with known elastolytic activities, and both enzymes have been identified in macrophages present in plaque areas of diseased blood vessels. Here we demonstrate ...
متن کاملA characterization of a pomonoid $S$ all of its cyclic $S$-posets are regular injective
This work is devoted to give a charcaterization of a pomonoid $S$ such that all cyclic $S$-posets are regular injective.
متن کاملCathepsin B and its role(s) in cancer progression.
Experimental and clinical evidence has linked cathepsin B with tumour invasion and metastasis. Cathepsin B expression is increased in many human cancers at the mRNA, protein and activity levels. In addition, cathepsin B is frequently overexpressed in premalignant lesions, an observation that associates this protease with local invasive stages of cancer. Increased expression of cathepsin B in pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2020
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bcj20190847